Steroid catabolic process

Across TCGA patient cohorts, RNA activity of the Steroid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, SLC11A1, and MILR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid catabolic process activity versus SPP1 in HNSC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPP1 →	+2.020	+1.122	.003	.002	3	8
BRCA	SLC11A1 →	+0.927	+0.917	<.001	<.001	3	7
LSCC	MILR1 →	+0.586	+0.301	.001	.002	3	7
GBM	AQP9 →	+1.194	+0.362	.003	<.001	3	6
GBM	CCL7 →	+0.883	+0.299	.006	.002	2	7
GBM	MMP8 →	+0.803	+0.327	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006706 vs SPP1 — HNSC

Explore this scatter interactively →