Steroid catabolic process

Across TCGA cell cohorts, RNA activity of the Steroid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0A2, ABCG4, and NUSAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V0A2 grouped by Steroid catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATP6V0A2 →	+0.379	+0.856	.005	.001	3	5
LIVER	ABCG4 →	+0.093	+1.472	<.001	<.001	3	4
BREAST	NUSAP1 →	+0.683	+0.778	.003	.002	2	5
BLOOD_Leukemia	DIMT1 →	+0.709	+0.859	.008	.007	3	4
BLOOD_Leukemia	CTBP2 →	+1.477	+0.903	.002	.004	3	4
BLOOD_Leukemia	RNASET2 →	-1.461	-0.733	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V0A2 by Steroid catabolic process activity — SKIN

Explore this box plot interactively →