Steroid catabolic process

Across TCGA cell cohorts, RNA activity of the Steroid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGDH, SLC1A3, and PLCH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid catabolic process activity versus UGDH in LUNG_NSCLC_LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UGDH →	+2.455	+0.887	<.001	.001	3	5
LUNG_NSCLC_LUAD	SLC1A3 →	-2.362	-0.822	.001	<.001	3	4
LUNG_NSCLC_LUAD	PLCH1 →	+1.272	+0.793	<.001	.003	3	4
LUNG_NSCLC_LUAD	AKR1C2 →	+4.986	+0.626	.001	.006	2	5
LUNG_NSCLC_LUAD	HPGD →	+2.077	+0.820	<.001	<.001	3	4
CNS	KYNU →	+3.108	+0.778	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006706 vs UGDH — LUNG_NSCLC_LUAD

Explore this scatter interactively →