Phosphatidylserine metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylserine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2_S363, EFEMP1, and UBE2S, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylserine metabolic process activity versus SYNPO2_S363 in LUAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SYNPO2_S363 →	+1.091	+0.064	<.001	<.001	3	6
GBM	EFEMP1 →	+0.567	+0.041	.009	.006	3	6
LUAD	UBE2S →	-0.558	-0.041	<.001	.001	3	5
LSCC	AKAP12_S612 →	+0.786	+0.051	<.001	<.001	3	5
GBM	F13A1 →	+1.037	+0.049	<.001	<.001	3	5
HNSC	SYTL2_S571 →	+1.161	+0.086	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006658 vs SYNPO2_S363 — LUAD

Explore this scatter interactively →