Phosphatidylglycerol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylglycerol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIX1L, MCM7, and ARHGDIB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol biosynthetic process activity versus LIX1L in OVARY (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LIX1L →	-1.354	-0.596	<.001	.005	3	4
SKIN	MCM7 →	-0.886	-0.390	.004	.003	3	4
OVARY	ARHGDIB →	+3.121	+0.590	<.001	.006	3	3
OVARY	PTK2B →	+0.893	+0.560	<.001	.009	3	3
CNS	CENPM →	-0.515	-0.268	.001	<.001	3	3
SKIN	GFI1B →	-0.096	-0.406	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006655 vs LIX1L — OVARY

Explore this scatter interactively →