Fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fatty acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S1132, SNX4, and GPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid biosynthetic process activity versus SRRM2_S1132 in GBM (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRRM2_S1132 →	-0.318	-0.041	<.001	<.001	3	6
OV	SNX4 →	+0.283	+0.020	.006	.003	3	6
GBM	GPD1 →	+0.869	+0.029	<.001	<.001	3	6
LSCC	PLEKHA6_S808 →	+0.816	+0.033	<.001	<.001	3	6
LSCC	RGN →	+0.593	+0.033	<.001	<.001	3	5
LUAD	RRP1B_S513 →	-0.900	-0.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006633 vs SRRM2_S1132 — GBM

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