Fatty acid biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Fatty acid biosynthetic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 167 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Fatty acid biosynthetic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and LIHC, show the opposite pattern, with higher activity associated with better survival.

LGG, BRCA, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.625	0.813	<.001	53	view →
BRCA	DFS	Tertile	III,IV	0.552	0.382	.014	48	view →
LIHC	OS	Quartile	All	0.855	0.669	.002	48	view →
SCLC	DFS	Tertile	III,IV	0.317	0.737	.001	47	view →
CESC	DFS	Quartile	III,IV	0.314	0.723	.001	42	view →
UVM	OS	Quartile	All	0.399	0.778	.004	42	view →
THCA	OS	Median	III,IV	0.712	0.946	.006	31	view →
UCEC	OS	Tertile	All	0.573	0.743	.002	24	view →
GBM	DFS	Quartile	All	0.179	0.480	.002	15	view →
MESO	OS	Tertile	All	0.998	0.373	.040	15	view →
READ	DFS	Median	III,IV	0.505	0.201	.022	13	view →
SARC	OS	Tertile	All	0.682	0.409	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0006633–LGG (DFS)

Open the LGG breakdown →