"SRP-dependent cotranslational protein targeting to membrane, translocation"

Across TCGA patient cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, translocation" pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADCY4, ARL15, and PTPRD-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "SRP-dependent cotranslational protein targeting to membrane, translocation" activity versus ADCY4 in CCRCC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ADCY4 →	-0.693	-0.223	<.001	<.001	3	4
CCRCC	ARL15 →	-0.494	-0.191	<.001	<.001	3	4
CCRCC	PTPRD-AS1 →	-0.388	-0.252	.003	.006	3	4
BRCA	SLC25A5P2 →	+0.866	+0.212	.002	<.001	3	4
OV	TAGLN2P1 →	+0.951	+0.089	.001	.007	3	4
BRCA	VDAC2P3 →	+0.408	+0.230	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006616 vs ADCY4 — CCRCC

Explore this scatter interactively →