"SRP-dependent cotranslational protein targeting to membrane, translocation"

Across TCGA pan-cancer cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, translocation" pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher "SRP-dependent cotranslational protein targeting to membrane, translocation" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRP, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.209	0.583	<.001	71	view →
KIRP	DFS	Quartile	All	0.519	0.825	<.001	66	view →
KIRC	OS	Median	All	0.553	0.686	<.001	62	view →
UCS	DFS	Quartile	III,IV	0.746	0.097	<.001	44	view →
HNSC	DFS	Median	All	0.540	0.224	.004	43	view →
PAAD	DFS	Quartile	II,III,IV	0.578	0.271	.011	32	view →
LUSC	DFS	Tertile	III,IV	0.475	0.787	.005	24	view →
STAD	DFS	Quartile	IV	0.838	0.150	.012	24	view →
SCLC	OS	Median	All	0.607	0.356	.005	22	view →
UCEC	DFS	Quartile	All	0.561	0.777	<.001	20	view →
THCA	OS	Median	All	0.960	0.992	.013	20	view →
BLCA	DFS	Median	All	0.192	0.544	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0006616–ACC (DFS)

Open the ACC breakdown →