NLS-bearing protein import into nucleus

Across TCGA patient cohorts, RNA activity of the NLS-bearing protein import into nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIF1_S2172, NCAPG_S674, and NCL_S67, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NLS-bearing protein import into nucleus activity versus RIF1_S2172 in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIF1_S2172 →	+0.628	+0.050	.004	.004	3	6
LUAD	NCAPG_S674 →	+0.758	+0.042	.001	.003	3	6
LUAD	NCL_S67 →	+0.805	+0.063	<.001	<.001	3	6
LUAD	TOP2A_S1247 →	+0.964	+0.046	.001	.002	3	6
LSCC	RIF1 →	+0.408	+0.049	.001	.002	2	6
UCEC	SMC2 →	+0.390	+0.057	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006607 vs RIF1_S2172 — LSCC

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