NLS-bearing protein import into nucleus

Across TCGA patient cohorts, RNA activity of the NLS-bearing protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSP1, CCDC69, and VSIR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NLS-bearing protein import into nucleus activity versus LSP1 in OV (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LSP1 →	-0.578	-0.148	.006	.002	3	6
LSCC	CCDC69 →	-0.733	-0.168	<.001	<.001	3	6
GBM	VSIR →	-0.790	-0.216	<.001	.009	3	6
LSCC	MS4A6A →	-0.797	-0.222	<.001	<.001	3	5
COAD	LILRA2 →	-0.432	-0.293	.005	.006	3	5
HNSC	SEH1L →	+0.360	+0.211	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006607 vs LSP1 — OV

Explore this scatter interactively →