GO:0006552Ontology (GO BP)GO biological process · ~6 member genes
Q-omics provides the L-leucine catabolic process (GO:0006552) pathway profile, scoring each patient from the combined activity of its roughly 6 member genes. Pathway activity is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 13, with the highest sampling consensus in KIRP. Additionally, pathway RNA activity shows 35,614 significant cross-omics associations, again with the highest sampling consensus in HNSC. Together, these results highlight KIRP, and HNSC as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes L-leucine catabolic process survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High L-leucine catabolic process activity shows favorable associations in KIRP, MESO, HNSC, READ and ESCA, but unfavorable associations in LGG. In the KIRP Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p < 0.001). KIRP ranks highest by sampling consensus for L-leucine catabolic process.
This table summarizes L-leucine catabolic process tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 13 cancer types, while mass-spec protein activity shows differences in 5. The strongest signals are in KIRP for RNA and HNSC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows consistently lower tumor activity across KIRP, HNSC, KICH, KIRC, THCA and LIHC. In the KIRP box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.117, t-test p < 0.001).
This table shows molecular features associated with L-leucine catabolic process pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in HNSC. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in BLOOD_Lymphoma.
