L-leucine catabolic process

Across TCGA patient cohorts, RNA activity of the L-leucine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AUH, RALGPS1, and TPX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-leucine catabolic process activity versus AUH in BRCA (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AUH →	+0.399	+0.106	<.001	<.001	3	8
HNSC	RALGPS1 →	+0.674	+0.102	.001	.001	3	6
LUAD	TPX2 →	-1.231	-0.122	<.001	.004	3	6
BRCA	PRKN →	+0.403	+0.131	<.001	<.001	3	6
COAD	SHCBP1 →	-0.536	-0.100	<.001	<.001	3	6
COAD	CDCA2 →	-0.556	-0.087	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006552 vs AUH — BRCA

Explore this scatter interactively →