L-leucine catabolic process

Across TCGA patient cohorts, RNA activity of the L-leucine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMGCL, LYPLA2, and GALE, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-leucine catabolic process activity versus HMGCL in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGCL →	+0.527	+0.102	<.001	<.001	3	9
BRCA	LYPLA2 →	+0.242	+0.050	.001	.002	3	7
LSCC	GALE →	+0.373	+0.043	<.001	<.001	3	7
BRCA	NMNAT1 →	+0.305	+0.044	<.001	<.001	3	6
BRCA	RBM47 →	+0.371	+0.049	<.001	.001	3	6
BRCA	TKFC →	+0.332	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006552 vs HMGCL — UCEC

Explore this scatter interactively →