Glutamine metabolic process

Across TCGA patient cohorts, RNA activity of the Glutamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETDB1_S1066, CAD_S1859, and BAZ1B_S349, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamine metabolic process activity versus SETDB1_S1066 in LUAD (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SETDB1_S1066 →	+0.672	+0.057	<.001	<.001	3	6
LUAD	CAD_S1859 →	+0.565	+0.049	<.001	<.001	3	6
BRCA	BAZ1B_S349 →	+0.924	+0.041	<.001	.001	3	6
LUAD	ASPSCR1_S275 →	+0.446	+0.067	<.001	<.001	3	5
UCEC	SHMT2 →	+0.513	+0.047	<.001	.001	3	5
UCEC	CEBPZ →	+0.254	+0.054	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006541 vs SETDB1_S1066 — LUAD

Explore this scatter interactively →