Glutamine metabolic process

Across TCGA cell cohorts, RNA activity of the Glutamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QBP, MYBBP1A, and ATP5F1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamine metabolic process activity versus C1QBP in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	C1QBP →	+1.299	+0.254	<.001	<.001	3	7
LIVER	MYBBP1A →	+1.355	+0.254	<.001	<.001	3	6
BONE	ATP5F1B →	+0.775	+0.405	.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	NUDT3 →	+0.818	+0.232	.001	<.001	3	6
LUNG_SCLC	DHODH →	+0.603	+0.267	.003	.005	3	5
OVARY	ENPP5 →	-1.679	-0.239	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006541 vs C1QBP — LIVER

Explore this scatter interactively →