Glutamate metabolic process

Across TCGA patient cohorts, RNA activity of the Glutamate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KCTD12, L2HGDH, and PHLDB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate metabolic process activity versus KCTD12 in LSCC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KCTD12 →	-0.339	-0.073	<.001	.001	3	8
LSCC	L2HGDH →	+0.355	+0.066	<.001	<.001	3	7
BRCA	PHLDB1 →	-0.352	-0.030	.002	.002	3	7
LSCC	ANXA6 →	-0.484	-0.095	<.001	<.001	3	7
LSCC	ATPAF1 →	+0.400	+0.077	<.001	<.001	3	6
LSCC	GOT2 →	+0.559	+0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006536 vs KCTD12 — LSCC

Explore this scatter interactively →