Glutamate metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Glutamate metabolic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 33 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Glutamate metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and LIHC, show the opposite pattern, with higher activity associated with better survival.

UVM, MESO, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.223	0.825	<.001	105	view →
MESO	DFS	Tertile	III,IV	0.563	0.275	.002	55	view →
LIHC	OS	Median	All	0.764	0.609	<.001	52	view →
UCS	DFS	Quartile	III,IV	0.160	0.679	<.001	46	view →
ACC	DFS	Median	II,III,IV	0.728	0.287	.001	39	view →
PAAD	DFS	Quartile	All	0.458	0.247	.005	29	view →
READ	DFS	Tertile	II,III,IV	0.823	0.245	.011	27	view →
ESCA	DFS	Quartile	II,III,IV	0.333	0.588	.008	25	view →
BLCA	DFS	Tertile	All	0.543	0.716	.007	20	view →
KIRC	DFS	Quartile	All	0.661	0.540	.016	19	view →
KIRP	OS	Median	All	0.962	0.624	.010	16	view →
THYM	OS	Tertile	II,III,IV	0.669	0.965	.016	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0006536–UVM (DFS)

Open the UVM breakdown →