Glutamate metabolic process

Across TCGA cell cohorts, RNA activity of the Glutamate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A3, FADS2, and EXD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC1A3 grouped by Glutamate metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC1A3 →	-0.223	-0.200	.002	.002	3	4
LUNG_NSCLC_LUSC	FADS2 →	-0.198	-0.225	.004	.008	3	4
BLOOD_Leukemia	EXD2 →	+0.181	+0.371	.006	.009	3	3
LARGE_INTESTINE	PSMB8 →	-0.177	-0.224	.002	.001	3	3
LUNG_SCLC	ZNF10 →	-0.219	-0.338	<.001	<.001	3	3
LUNG_NSCLC_LUAD	NADK →	-0.134	-0.243	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC1A3 by Glutamate metabolic process activity — LIVER

Explore this box plot interactively →