Glutamate metabolic process

Across TCGA cell cohorts, RNA activity of the Glutamate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDZD8, PCGF5, and PI4K2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate metabolic process activity versus PDZD8 in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDZD8 →	+1.160	+0.230	.002	<.001	3	5
BLOOD_Leukemia	PCGF5 →	+1.320	+0.228	.002	.001	3	5
LUNG_NSCLC_LUSC	PI4K2A →	+0.717	+0.200	.003	.006	3	5
STOMACH	PPARA →	+0.980	+0.157	.006	.007	2	6
BLOOD_Leukemia	LRRC42 →	+0.793	+0.251	.001	.002	3	4
BREAST	MTHFD1L →	+1.668	+0.234	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006536 vs PDZD8 — BLOOD_Leukemia

Explore this scatter interactively →