Aspartate metabolic process

Across TCGA patient cohorts, RNA activity of the Aspartate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, CLUH, and ESF1_S153, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate metabolic process activity versus RPL12_S38 in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPL12_S38 →	+0.803	+0.066	.002	.003	3	7
BRCA	CLUH →	+0.390	+0.102	<.001	<.001	3	7
BRCA	ESF1_S153 →	+0.793	+0.079	<.001	<.001	3	7
LSCC	SLIRP →	+0.474	+0.090	<.001	<.001	3	7
OV	LRP1 →	-0.459	-0.048	<.001	.009	3	7
COAD	SYNPO2 →	-0.830	-0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006531 vs RPL12_S38 — PDAC

Explore this scatter interactively →