N-glycan processing

Across TCGA patient cohorts, RNA activity of the N-glycan processing pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU7-113P, MSH5, and LRATD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-glycan processing activity versus RNU7-113P in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU7-113P →	-0.716	-0.118	.003	.008	3	4
COAD	MSH5 →	-0.468	-0.162	.006	.008	3	4
OV	LRATD1 →	-0.955	-0.189	.006	<.001	3	3
GBM	OBSCN-AS1 →	-0.244	-0.152	.005	.005	3	3
GBM	ZSWIM1 →	-0.227	-0.130	.002	.008	3	3
GBM	RNVU1-3 →	-0.465	-0.196	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006491 vs RNU7-113P — LUAD

Explore this scatter interactively →