Protein methylation

Across TCGA patient cohorts, RNA activity of the Protein methylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POLR2A, RFC1_S368, and RSBN1_S81, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein methylation activity versus POLR2A in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLR2A →	+0.206	+0.870	<.001	<.001	3	7
GBM	RFC1_S368 →	+0.605	+0.705	<.001	<.001	3	6
LUAD	RSBN1_S81 →	+0.561	+0.702	<.001	<.001	3	6
LSCC	SF3B6 →	+0.282	+1.117	<.001	<.001	3	6
GBM	SNRNP200 →	+0.232	+0.847	<.001	<.001	3	6
OV	SNRPD1 →	+0.500	+0.751	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006479 vs POLR2A — LSCC

Explore this scatter interactively →