Protein methylation

Across TCGA pan-cancer cohorts, RNA activity of the Protein methylation pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and KICH, show the opposite pattern, with lower activity in tumor tissue.

THCA, KICH, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Female	II,III,IV	−0.033	<.001	11	view →
KICH	All	All	−0.051	<.001	10	view →
COAD	All	IV	+0.032	<.001	10	view →
KIRC	Male	II,III,IV	−0.016	<.001	7	view →
LIHC	Female	II,III,IV	+0.029	<.001	6	view →
CHOL	All	All	+0.062	<.001	4	view →
LUAD	All	All	+0.026	<.001	4	view →
LUSC	All	All	+0.024	<.001	4	view →
HNSC	All	III,IV	+0.022	.007	4	view →
BLCA	All	III,IV	+0.030	.013	3	view →
KIRP	All	All	−0.022	.001	2	view →
PRAD	All	All	+0.014	.007	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0006479–THCA

Open the THCA breakdown →