Translational readthrough

Across TCGA patient cohorts, RNA activity of the Translational readthrough pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, TRIP13, and FKBP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational readthrough activity versus SYNPO in PDAC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SYNPO →	+0.326	+0.042	.001	<.001	3	5
BRCA	TRIP13 →	-0.397	-0.036	<.001	<.001	3	5
BRCA	FKBP7 →	+0.402	+0.044	<.001	<.001	3	5
COAD	SYNPO2_S264 →	+0.766	+0.038	<.001	<.001	3	4
LSCC	TK1 →	-0.406	-0.051	.003	<.001	3	4
BRCA	TPM4 →	+0.570	+0.051	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006451 vs SYNPO — PDAC

Explore this scatter interactively →