Translational readthrough

Across TCGA pan-cancer cohorts, RNA activity of the Translational readthrough pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher Translational readthrough pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCEC and KIRP, show the opposite pattern, with higher activity associated with better survival.

DLBC, UCEC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	All	0.450	0.973	<.001	68	view →
UCEC	OS	Quartile	II,III,IV	0.975	0.809	.002	64	view →
KIRP	DFS	Quartile	All	1.000	0.672	.007	41	view →
MESO	OS	Tertile	All	0.476	0.197	.002	33	view →
THCA	DFS	Tertile	II,III,IV	0.843	0.957	<.001	31	view →
COAD	OS	Median	II,III,IV	0.904	0.810	.006	25	view →
ACC	OS	Median	All	0.876	0.720	.013	25	view →
CESC	OS	Quartile	IV	0.792	0.254	.008	18	view →
SKCM	OS	Median	III,IV	0.519	0.285	.001	18	view →
THYM	DFS	Tertile	All	1.000	0.706	.024	14	view →
UVM	DFS	Tertile	III,IV	0.111	0.699	.004	12	view →
ESCA	OS	Tertile	III,IV	0.742	0.376	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0006451–DLBC (DFS)

Open the DLBC breakdown →