RNA export from nucleus

Across TCGA cell cohorts, RNA activity of the RNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27L, USP49, and LRP10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA export from nucleus activity versus RPS27L in CNS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPS27L →	-0.735	-0.177	.007	.002	3	7
BREAST	USP49 →	+0.883	+0.217	.001	<.001	3	7
BONE	LRP10 →	-2.374	-0.211	<.001	.003	3	6
BONE	CST3 →	-1.720	-0.214	<.001	.002	3	6
BONE	CPEB4 →	-1.552	-0.205	.003	.004	3	6
BONE	COPS7B →	+1.001	+0.331	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006405 vs RPS27L — CNS

Explore this scatter interactively →