Termination of RNA polymerase II transcription

Across TCGA patient cohorts, RNA activity of the Termination of RNA polymerase II transcription pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM33_S862, MCM3, and DDX56, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Termination of RNA polymerase II transcription activity versus TRIM33_S862 in PDAC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TRIM33_S862 →	+0.498	+0.057	<.001	<.001	3	8
LSCC	MCM3 →	+0.774	+0.082	<.001	<.001	3	8
LSCC	DDX56 →	+0.286	+0.072	<.001	<.001	3	8
LSCC	SETDB1_S1066 →	+0.994	+0.091	<.001	<.001	3	8
GBM	SMC4 →	+0.676	+0.049	<.001	<.001	3	8
LSCC	TTF2 →	+0.407	+0.076	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006369 vs TRIM33_S862 — PDAC

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