"Nucleotide-excision repair, DNA gap filling"

Across TCGA patient cohorts, RNA activity of the "Nucleotide-excision repair, DNA gap filling" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LIG1, POLD1, and RRM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nucleotide-excision repair, DNA gap filling" activity versus LIG1 in GBM (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LIG1 →	+0.569	+0.078	<.001	<.001	3	8
GBM	POLD1 →	+0.454	+0.079	<.001	<.001	3	7
GBM	RRM2 →	+0.786	+0.086	<.001	<.001	3	7
LUAD	SMC4 →	+0.465	+0.077	<.001	<.001	3	7
GBM	TFDP1_S23 →	+0.772	+0.083	<.001	<.001	3	7
PDAC	MCM7 →	+0.606	+0.067	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006297 vs LIG1 — GBM

Explore this scatter interactively →