Regulation of DNA replication

Across TCGA cell cohorts, RNA activity of the Regulation of DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1G, SUPT16H, and XRCC6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA replication activity versus PPM1G in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPM1G →	+0.700	+0.301	<.001	<.001	3	7
PANCREAS	SUPT16H →	+0.877	+0.223	.006	<.001	3	7
LUNG_NSCLC_LUAD	XRCC6 →	+0.476	+0.159	.003	.002	3	7
LUNG_NSCLC_LUAD	PGAM5 →	+0.630	+0.225	.003	<.001	3	7
OVARY	EIF4H →	+0.746	+0.244	<.001	<.001	3	6
SKIN	MCM7 →	+0.739	+0.239	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006275 vs PPM1G — BREAST

Explore this scatter interactively →