DNA topological change

Across TCGA patient cohorts, RNA activity of the DNA topological change pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, FANCD2, and SPC25, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA topological change activity versus TTK in LSCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TTK →	+1.133	+0.321	<.001	<.001	3	8
LSCC	FANCD2 →	+0.947	+0.339	<.001	<.001	3	8
LSCC	SPC25 →	+1.024	+0.376	<.001	<.001	3	8
GBM	CDC25C →	+0.877	+0.358	<.001	<.001	3	8
GBM	SKA3 →	+1.061	+0.369	<.001	<.001	3	8
LSCC	FANCB →	+0.977	+0.319	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006265 vs TTK — LSCC

Explore this scatter interactively →