DNA topological change

Across TCGA cell cohorts, RNA activity of the DNA topological change pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP2B, BRPF1, and C21orf91, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA topological change activity versus TOP2B in BLOOD_Leukemia (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TOP2B →	+1.088	+0.233	<.001	<.001	3	8
BLOOD_Leukemia	BRPF1 →	+0.456	+0.183	<.001	<.001	3	7
BREAST	C21orf91 →	+1.606	+0.234	.001	.004	3	6
BREAST	SIN3A →	+0.495	+0.157	.003	.004	3	6
KIDNEY	HNRNPUL1 →	+1.324	+0.341	.002	.005	3	5
KIDNEY	CAPN7 →	+1.198	+0.396	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006265 vs TOP2B — BLOOD_Leukemia

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