DNA-templated DNA replication

Across TCGA patient cohorts, RNA activity of the DNA-templated DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RPL12_S38, and RRM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated DNA replication activity versus RFC2 in LSCC (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.441	+0.081	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.420	+0.109	<.001	<.001	3	10
LUAD	RRM2 →	+1.041	+0.116	<.001	<.001	3	10
LUAD	SETDB1_S1066 →	+0.995	+0.103	<.001	<.001	3	10
LUAD	SMC2 →	+0.769	+0.121	<.001	<.001	3	10
LUAD	SMC4 →	+0.756	+0.118	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006261 vs RFC2 — LSCC

Explore this scatter interactively →