"Mitochondrial electron transport, ubiquinol to cytochrome c"

Across TCGA patient cohorts, RNA activity of the "Mitochondrial electron transport, ubiquinol to cytochrome c" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COX7A2L, COQ6, and ATP5PF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, ubiquinol to cytochrome c" activity versus COX7A2L in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COX7A2L →	+0.383	+0.054	.001	<.001	3	5
UCEC	COQ6 →	+0.225	+0.087	.005	.003	2	5
HNSC	ATP5PF →	+0.181	+0.057	.003	<.001	3	4
PDAC	YAP1_S382 →	-0.370	-0.031	.003	.005	3	4
CCRCC	ATP5PD →	+0.242	+0.028	.007	.007	2	5
GBM	MMP14 →	-0.491	-0.038	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006122 vs COX7A2L — OV

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