"Mitochondrial electron transport, ubiquinol to cytochrome c"

Across TCGA cell cohorts, RNA activity of the "Mitochondrial electron transport, ubiquinol to cytochrome c" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H3, SLC52A2, and CEBPD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, ubiquinol to cytochrome c" activity versus ZC3H3 in BLOOD_Lymphoma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZC3H3 →	+0.802	+0.239	<.001	<.001	3	7
LIVER	SLC52A2 →	+1.173	+0.297	.001	.001	3	6
BLOOD_Leukemia	CEBPD →	+2.157	+0.305	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	ST6GALNAC5 →	-1.218	-0.177	<.001	.005	3	6
BLOOD_Leukemia	BLVRB →	+2.961	+0.290	<.001	<.001	3	5
BLOOD_Lymphoma	EXOSC4 →	+1.047	+0.202	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006122 vs ZC3H3 — BLOOD_Lymphoma

Explore this scatter interactively →