Regulation of gluconeogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRIM1, RPL12P11, and CDCA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gluconeogenesis activity versus PRIM1 in GBM (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRIM1 →	+0.434	+0.147	.008	.003	3	4
CCRCC	RPL12P11 →	+0.288	+0.639	.008	.001	3	4
GBM	CDCA3 →	+0.680	+0.248	<.001	<.001	3	4
UCEC	DDIT4L →	-1.467	-0.187	<.001	<.001	3	4
UCEC	CHST15 →	-0.993	-0.167	.002	.004	3	4
LSCC	MICAL2 →	-0.616	-0.185	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006111 vs PRIM1 — GBM

Explore this scatter interactively →