Regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVOL2, TMC4, and CTNNAL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OVOL2 grouped by Regulation of gluconeogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OVOL2 →	+2.623	+0.334	<.001	.003	3	5
LIVER	TMC4 →	+2.118	+0.284	.002	.002	3	5
LUNG_NSCLC_LUSC	CTNNAL1 →	-1.451	-0.284	.002	<.001	3	5
LUNG_NSCLC_LUSC	LNX2 →	+0.676	+0.265	.004	.001	3	5
SOFT_TISSUE	CPSF1 →	+0.718	+0.303	.002	<.001	3	5
KIDNEY	MIPEP →	+0.621	+0.226	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OVOL2 by Regulation of gluconeogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →