Regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALBP1, LAP3, and CSNK2A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gluconeogenesis activity versus RALBP1 in OVARY (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RALBP1 →	-0.783	-0.412	<.001	.005	3	4
LIVER	LAP3 →	-1.323	-0.342	.003	.004	3	4
OESOPHAGUS	CSNK2A1 →	-0.934	-0.288	<.001	.006	3	3
BLOOD_Leukemia	C14orf132 →	+1.251	+0.198	.001	.009	3	3
BONE	CNTNAP1 →	+1.631	+0.171	.002	.009	3	3
STOMACH	CCHCR1 →	+0.780	+0.214	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006111 vs RALBP1 — OVARY

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