Cellular aldehyde metabolic process

Across TCGA patient cohorts, RNA activity of the Cellular aldehyde metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF8, ARHGEF37_S251, and PRPF3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular aldehyde metabolic process activity versus PRPF8 in GBM (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRPF8 →	-0.167	-0.028	<.001	.001	3	8
CCRCC	ARHGEF37_S251 →	+0.916	+0.058	<.001	<.001	3	8
GBM	PRPF3 →	-0.175	-0.038	.001	<.001	3	8
GBM	CEP170 →	-0.349	-0.055	<.001	<.001	3	7
LSCC	ALDH1A1 →	+0.628	+0.046	<.001	<.001	3	7
PDAC	PBLD →	+0.565	+0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006081 vs PRPF8 — GBM

Explore this scatter interactively →