Cellular aldehyde metabolic process

Across TCGA patient cohorts, RNA activity of the Cellular aldehyde metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF20A, MYBL2, and EZH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular aldehyde metabolic process activity versus KIF20A in BRCA (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF20A →	-0.948	-0.208	.001	<.001	3	7
LUAD	MYBL2 →	-1.100	-0.154	<.001	<.001	3	6
GBM	EZH2 →	-0.684	-0.140	<.001	<.001	3	6
LUAD	UBE2S →	-0.726	-0.148	.003	.002	3	6
UCEC	NSD2 →	-0.429	-0.127	<.001	<.001	3	6
GBM	LMNB1 →	-0.761	-0.152	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006081 vs KIF20A — BRCA

Explore this scatter interactively →