Ethanol catabolic process

Across TCGA patient cohorts, RNA activity of the Ethanol catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULT1A1, ALDH3B1, and TRIM28_S683, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ethanol catabolic process activity versus SULT1A1 in OV (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SULT1A1 →	+0.897	+0.299	<.001	<.001	3	7
COAD	ALDH3B1 →	+0.850	+0.261	<.001	<.001	3	6
OV	TRIM28_S683 →	-1.360	-0.258	<.001	<.001	3	4
LSCC	IWS1_S400 →	-1.082	-0.163	<.001	<.001	3	4
GBM	CHD7_S2956 →	-0.658	-0.213	<.001	<.001	3	3
GBM	EHD4 →	+0.400	+0.265	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006068 vs SULT1A1 — OV

Explore this scatter interactively →