Ethanol metabolic process

Across TCGA cell cohorts, RNA activity of the Ethanol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH2, SPDYE16, and ALDH1B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ethanol metabolic process activity versus ALDH2 in BREAST (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ALDH2 →	+3.437	+1.037	<.001	<.001	3	6
KIDNEY	SPDYE16 →	-0.248	-1.400	.001	.003	3	4
LUNG_NSCLC_LUAD	ALDH1B1 →	+1.071	+0.870	<.001	.002	3	4
CNS	MACF1 →	-1.028	-1.110	<.001	.004	3	4
CNS	PHAX →	-0.422	-0.795	.003	.005	3	4
BLOOD_Leukemia	RC3H2 →	-0.830	-1.045	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006067 vs ALDH2 — BREAST

Explore this scatter interactively →