Glycosaminoglycan catabolic process

Across TCGA patient cohorts, RNA activity of the Glycosaminoglycan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD209, STAB1, and CD93, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosaminoglycan catabolic process activity versus CD209 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD209 →	+0.491	+0.141	.001	.001	3	7
GBM	STAB1 →	+1.005	+0.267	<.001	<.001	3	6
GBM	CD93 →	+0.770	+0.270	<.001	<.001	3	5
OV	LILRB5 →	+0.559	+0.207	.002	.005	3	5
UCEC	FAM20A →	+0.715	+0.155	.005	.003	3	5
GBM	RNASE1 →	+0.952	+0.176	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006027 vs CD209 — BRCA

Explore this scatter interactively →