Glycosaminoglycan catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Glycosaminoglycan catabolic process pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 28 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Glycosaminoglycan catabolic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and KIRP, show the opposite pattern, with higher activity associated with better survival.

BLCA, STAD, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.254	0.449	<.001	86	view →
STAD	DFS	Tertile	All	0.233	0.429	.001	46	view →
LGG	DFS	Median	All	0.772	0.888	<.001	37	view →
CESC	DFS	Median	II,III,IV	0.353	0.611	.008	32	view →
SKCM	OS	Median	All	0.412	0.270	.001	26	view →
ACC	DFS	Median	III,IV	0.169	0.524	.012	21	view →
KIRC	OS	Median	All	0.542	0.676	.008	18	view →
KIRP	DFS	Median	All	0.953	0.866	.004	14	view →
LUAD	OS	Median	II,III,IV	0.170	0.323	.016	13	view →
COAD	DFS	Quartile	III,IV	0.687	0.394	.014	11	view →
READ	DFS	Median	All	0.753	0.478	.027	10	view →
PAAD	OS	Median	II,III,IV	0.753	0.467	.001	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0006027–BLCA (OS)

Open the BLCA breakdown →