Detection of calcium ion

Across TCGA cell cohorts, RNA activity of the Detection of calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR12, PCLAF, and R3HDM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of calcium ion activity versus WDR12 in BONE (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	WDR12 →	-1.000	-1.702	.009	<.001	3	4
LARGE_INTESTINE	PCLAF →	-2.366	-0.522	.003	.004	3	4
LARGE_INTESTINE	R3HDM1 →	-1.486	-0.500	.005	.006	2	4
LIVER	TUT4 →	-1.164	-0.499	.006	.009	3	3
LIVER	CFAP251 →	+2.865	+0.499	.005	.009	2	4
BLOOD_Leukemia	WNT4 →	+0.096	+1.874	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005513 vs WDR12 — BONE

Explore this scatter interactively →