Growth plate cartilage development

Across TCGA cell cohorts, RNA activity of the Growth plate cartilage development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR3A1, HDAC1, and FLRT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR3A1 grouped by Growth plate cartilage development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR3A1 →	+0.232	+0.838	.002	.007	2	4
OESOPHAGUS	HDAC1 →	+0.171	+1.808	.001	<.001	3	3
PANCREAS	FLRT2 →	+0.180	+1.912	.001	<.001	3	3
OESOPHAGUS	YWHAEP1 →	+0.185	+1.808	.005	<.001	3	3
OESOPHAGUS	DECR2 →	+0.201	+1.808	.004	<.001	3	3
BREAST	TBP →	+0.144	+0.893	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR3A1 by Growth plate cartilage development activity — BREAST

Explore this box plot interactively →