Positive regulation of cilium movement

Across TCGA patient cohorts, RNA activity of the Positive regulation of cilium movement pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEFB1, ZBTB21, and IGFBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cilium movement activity versus DEFB1 in BRCA (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DEFB1 →	+5.829	+0.537	.001	.001	3	4
HNSC	ZBTB21 →	+0.777	+0.358	<.001	<.001	3	3
GBM	IGFBP2 →	-2.773	-0.470	.001	.005	3	3
GBM	AGTPBP1 →	+0.949	+0.372	<.001	.001	3	3
LSCC	TEC →	+0.535	+0.216	.001	<.001	3	3
HNSC	SERPINE2 →	-2.909	-0.466	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003353 vs DEFB1 — BRCA

Explore this scatter interactively →