Regulation of cilium movement

Across TCGA cell cohorts, RNA activity of the Regulation of cilium movement pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDAH2, GJA3, and MKX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDAH2 grouped by Regulation of cilium movement-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DDAH2 →	-1.098	-1.086	.001	.009	2	5
BLOOD_Leukemia	GJA3 →	-0.651	-0.971	.003	.002	3	4
SOFT_TISSUE	MKX →	-2.717	-1.491	.005	<.001	3	4
BREAST	DAAM2 →	-0.755	-0.665	.004	.008	3	3
BREAST	KREMEN1 →	-1.039	-0.782	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	RAB2A →	-0.813	-1.183	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDAH2 by Regulation of cilium movement activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →