Cardiac septum cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac septum cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C12orf45, CPSF6, and CNOT6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac septum cell differentiation activity versus C12orf45 in CCRCC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C12orf45 →	+0.240	+0.115	.005	.007	3	5
LUAD	CPSF6 →	+0.470	+0.171	.001	.001	3	4
LSCC	CNOT6 →	+0.493	+0.289	<.001	<.001	3	4
LUAD	UBTD2 →	+0.466	+0.228	<.001	<.001	3	4
LUAD	UIMC1 →	+0.264	+0.140	<.001	.002	3	4
LSCC	C6orf62 →	+0.356	+0.191	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003292 vs C12orf45 — CCRCC

Explore this scatter interactively →