Cardiac septum cell differentiation

Across TCGA cell cohorts, RNA activity of the Cardiac septum cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM10, BANK1, and FBXO22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LSM10 grouped by Cardiac septum cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LSM10 →	+0.462	+0.444	.003	.002	3	5
STOMACH	BANK1 →	-1.672	-2.131	.006	<.001	3	4
OVARY	FBXO22 →	+0.828	+1.214	.008	.001	3	4
LUNG_NSCLC_LUAD	LHFPL5 →	-0.376	-0.574	.001	.007	3	3
BONE	RHBG →	-0.115	-1.119	.002	.008	3	3
SKIN	STIP1 →	+0.531	+0.564	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LSM10 by Cardiac septum cell differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →